Clinical Trials

Supported by Clinical Trials and Testing

International Journal of Pain
The International Journal of Pain reviewed a study that features 63 patients who experienced neuropathic pain. Over the course of 52 weeks, they were given CBD oil similar to what is in this formula. At the end of the 52 weeks, the participants reported feeling less pain and they also claimed that they did not develop any dependency toward the formula.

Journal of Biochemistry and Cell Biology
The Journal of Biochemistry and Cell Biology featured another study that found that cannabinoid compounds are an ideal approach to treating neuropathic pain. The participants in that study experienced a significant reduction in pain levels while taking CBD.

Journal of Pharmacology
Finally, the Journal of Pharmacology featured another study that commented upon the therapeutic use of CBD and its ability to reduce painful states.

Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial

RJ Ellis, W Toperoff, F Vaida… - …, 2009 - nature.com
Abstract Despite management with opioids and other pain modifying therapies, neuropathic 
pain continues to reduce the quality of life and daily functioning in HIV-infected individuals. 
Cannabinoid receptors in the central and peripheral nervous systems have been shown to 
DI Abrams, CA Jay, SB Shade, H Vizoso, H Reda… - Neurology, 2007 - AAN Enterprises
... 2 and –1) in which patients were acclimated to the inpatient General Clinical Research Center
setting ... A >30% reduction in pain has been validated as a clinically significant level of improvement. ...
25,26 A recent meta-analysis of 107 controlled trials for neuropathic pain showed ...
D Selvarajah, R Gandhi, CJ Emery, S Tesfaye - Diabetes care, 2010 - Am Diabetes Assoc
OBJECTIVE To assess the efficacy of Sativex, a cannabis-based medicinal extract, as 
adjuvant treatment in painful diabetic peripheral neuropathy (DPN). RESEARCH DESIGN 
AND METHODS In this randomized controlled trial, 30 subjects with painful DPN received 

The medicinal use of cannabis in the UK: results of a nationwide survey

MA Ware, H Adams, GW Guy - International journal of clinical …, 2005 - Wiley Online Library
... Finally, recent randomised controlled clinical trials have pointed to potential therapeutic benefits
of cannabinoids for ... Cannabis for chronic pain: case series and implications for clinicians...
Mary-Jane and her patients: sociodemographic and clinical characteristics of HIV-positive ...
F Strasser, D Luftner, K Possinger, G Ernst… - Journal of Clinical …, 2006 - ascopubs.org
... random assignment, unblinding, and related decisions were naive to clinical evaluations and ...
were calculated as flagging devices to mark conspicuous, potentially clinically relevant differences. ...
Like previous trials for symptom control, our study showed significant PL effects. ...

Medicinal Plants

IA Ross - 2005 - Springer
... 9 References..... 19 2 Cannabis sativa..... ... 119 Traditional Medicinal Uses..... ...
120 Pharmacological Activities and Clinical Trials..... ...

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

MA Ware, T Wang, S Shapiro, A Robinson… - Canadian Medical …, 2010 - Can Med Assoc
... Instead, our data suggest that short-term placebo-controlled trials of smoked cannabis are ...
Cannabis for chronic pain: case series and implications for clinicians... treats neuropathic pain
characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial...

Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

JS Berman, C Symonds, R Birch - Pain, 2004 - Elsevier
... Depending upon their clinical response to the dose of study medication given in the clinic each ...
11 pain score between the active and placebo phases would represent a clinically significant
change ... In trials conducted to date using GW-1000-02, the putative effective half-lives of ...

Human studies of cannabinoids and medicinal cannabis

P Robson - Cannabinoids, 2005 - Springer
... More and more scientists and clinicians are becoming interested in exploring the potential of ...
International Congress. Penta JS, Poster DS, Bruno S, et al (1981) Clinical trials with anti ... Addiction
92:1729–1736PubMedCrossRef. Robson P, Guy GW (2004) Clinical studies of ...
DI Abrams, JF Hilton, RJ Leiser… - Annals of internal …, 2003 - Am Coll Physicians
... Acknowledgments: The authors thank the research nursing and dietary staff at the
San Francisco General Hospital General Clinical Research Center for the
professionalism and compassion with which they conducted the trial...


Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis‐Based Medicine

EB Russo, GW Guy, PJ Robson - Chemistry & biodiversity, 2007 - Wiley Online Library
... Visual Analogue Scales (VASs) and Numerical Rating Scales (NRSs) are familiar instruments
to many clinicians and have traditionally ... No head-to-head trials of Sativex vs. ... Data from the clinical
research on Sativex reviewed in this article are not consistent with this conclusion. ...

W Notcutt, M Price, R Miller, S Newport, C Phillips… - …, 2004 - Wiley Online Library
... asked not to change their regular medication without prior discussion with the research team ... The
patients were then discharged home with a relative if in a clinically satisfactory state ... Where clinical
benefit could be shown for individual patients, they were offered the opportunity to ...

Medicinal cannabis extracts for the treatment of multiple sclerosis.

PF Smith - Current opinion in investigational drugs (London, …, 2004 - europepmc.org
... does not act on the CB1 receptor, can produce a statistically and clinically significant reduction ...
Nonetheless, results of preclinical trials also lend support to the hypothesis that the endogenous ...
cannabis extracts will have to await the publication of the most recent clinical trial data ...
EA Voth, RH Schwartz - Annals of Internal Medicine, 1997 - Am Coll Physicians
... Methods. Resources discussing the medicinal applications of pure THC and marijuana were
identified from our personal libraries and by searching MEDLINE for research published between
1975 ... Any clinical trials that involved the use of crude marijuana were included. ...
AJ Clark, MA Ware, E Yazer, TJ Murray, ME Lynch - Neurology, 2004 - AAN Enterprises
... A large randomized controlled trial (n = 660) recently compared the effects of oral cannabis
extracts ... Clinical trials of cannabis for MS will need to include early dose-finding phases and allow
for ... en Santé du Québec (FRSQ) and the Canadian Institutes of Health Research (CIHR ...
DR Blake, P Robson, M Ho, RW Jubb… - …, 2006 - Br Soc Rheumatology
... Royal National Hospital for Rheumatic Diseases, Bath, 1 Cannabinoid Research Institute, Oxford ...
Evidence from basic science and human trials suggests that cannabis-based medicines (CBM ...
CBD was found to block progression of disease and produce clinical improvement in ...
P Robson - The British Journal of Psychiatry, 2001 - RCP
... Medline literature search, reference lists supplied by the DOH and the Institute for the Study of
Drug Dependence, and personal communications with relevant academics and clinicians). ...
CLINICAL APPLICATIONS. ... Human randomised controlled trials (RCTs): anti-emetic effects. ...
GT Carter, P Weydt, M Kyashna-Tocha, DI Abrams - IDrugs, 2004 - coscc.org
... In using our dosing guidelines clinicians must be aware that THC is not the only clinically useful
and pharmacologically activecannabinoid. ... Ann Intern Med (2003) 139(4):258- 266. •• This is a
major clinical trial examining the effects of cannabinoids in the HIV-infected
LM Borgelt, KL Franson… - … : The Journal of …, 2013 - Wiley Online Library
... The patients that are enrolled in US medical cannabis studies are provided with a cannabis strain
or blend grown and created under contract at a federal research farm at the University of ... No
clinically apparent drug interactions were noted in clinical trials where nabiximols 
MA Ware, CR Doyle, R Woods, ME Lynch, AJ Clark - Pain, 2003 - Elsevier
... Controlled clinical trials and long term surveillance studies are needed to supply this ... in part by
the Faculty of Medicine, Dalhousie University, Canada's research-based pharmaceutical ...
Mary-Jane and her patients: sociodemographic and clinical characteristics of HIV-positive



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